From 1/1/2002 through 12/31/2011, National Highway Traffic Safety [sic] Administration statistics show that 392,621 people were killed by motor vehicle collisions in the United States. So, that’s about 100 9/11s. (And it does not count those who died from automotive air pollution and physical deconditioning.)
The all-time death toll from car crashes, going back to 1899? 3,547,113.
The news reporting on this topic? Such as it is, it’s all just a series of terrific news, especially now that the deaths-per-miles trick has been swallowed and adopted by the corporate press. (See the typical packaging of the story in the second link above.)